Whereas lower-depend MBL seldom progresses to CLL, significant-rely MBL progresses to CLL necessitating therapy in a fee of one% to two% annually. Superior-depend MBL is distinguished from Rai 0 CLL according to whether the B-cell count is above or below five × 109/L. Whilst people today with both of those large-rely MBL and CLL Rai stage 0 are at